Журнал "Гастроэнтерология" Том 56, №3, 2022

Стаття присвячена вивченню вмісту фекальних коротколанцюгових жирних кислот (SCFA) та їх зв’язку з інсулінорезистентністю в дітей з ожирінням. Установлено, що кишкова мікрофлора в дітей з ожирінням характеризується змінами якісного складу та зростанням метаболічної активності кишкової мікрофлори. Помірне підвищення HOMA-IR супроводжується зростанням концентрації прозапальних цитокінів, уміст яких корелює з умістом оцтової, пропіонової кислот, та зниженням метаболічної активності кишкової мікрофлори. Прогресування інсулінорезистентності супроводжується подальшим зростанням концентрації прозапальних цитокінів, рівень HOMA-IR корелює з умістом пропіонової SCFA. Отже, модуляція вмісту SCFA може бути перспективним способом терапевтичного впливу з метою корекції інсулінорезистентності та ожиріння в дітей.

The article deals with the study on the content of fecal short-chain fatty acids (SCFA) and their association with insulin resistance in obese children. It was found that intestinal microflora in obese children is characterized by changes in the qualitative composition and increased metabolic activity of the intestinal microflora. A moderate increase of HOMA-IR is accompanied by elevated concentration of anti-inflammatory cytokines, the content of which correlates with that of acetic, propionic acid and a decrease in the metabolic activity of intestinal microflora. The progression of insulin resistance is accompanied by a further increase in the concentration of anti-inflammatory cytokines, the level of HOMA-IR correlates with the level of propionic SCFA. Thus, modulation of SCFA content may be a promising way of therapeutic influence to correct insulin resistance and obesity in children.

ожиріння; діти; кишкова мікробіота; інсулінорезистентність

obesity; children; intestinal microbiota; insulin resistance

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